FIELD: bioengineering.
SUBSTANCE: method of fugu toxin production provides for extraction of fugu toxin containing bacteria from the fugu toxin containing carriers, and their location on substratum for cultivation and fugu toxin extraction from the understratum. The bacteria of genus Bacillus are used as containing bacteria, their cultivation is performed to the stage of spore formation under conditions stimulating spore formation. Stimulation of the spore formation to increase fugu toxin yield value can be made, in particular, by use of medium of spore formation adjuvant, by thermal shock, long-term cultivation, by addition of the sporulating salt, nucleosides, bacterial lysates, by bacteria transfer to the distilled water. Wherein prior to fugu toxin extraction from the substratum it is necessary to extract the sporiferous clean strains of bacteria of genus Bacillus, each of them for the fugu toxin cultivation is located on the separate substratum.
EFFECT: invention increases yield value of fugu toxin, and simplifies the method of its production.
6 cl, 3 dwg, 8 ex
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