FIELD: chemistry.
SUBSTANCE: invention relates to a method of synthesising nucleic acid, containing a chiral X-phosphonate constituent, which can be used in the pharmaceutical industry. The claimed method includes the reaction of a molecule, which contains an achiral H-phosphonate constituent, a chiral agent, a condensing reagent, which activates the molecule, containing the achiral H-phosphonate constituent for the reaction with the said chiral reagent, and nucleoside, containing a 5'-OH constituent, with obtaining a condensed intermediate compound, and conversion of the said condensed intermediate compound into nucleic acid, which contains the chiral X-phosphonate constituent.
EFFECT: claimed is the novel effective method of obtaining modified nucleic acids.
64 cl, 58 dwg, 3 tbl, 111 ex
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