FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology and medicine. Disclosed is a compound conjugated with three N-acetyl galactosamine ligands. Compound has structure XXVI:
,
where T2 represents a group containing a nucleoside, a nucleotide, a monomer subunit, a reactive ester, a linker, a splitted fragment or an oligomeric compound.
EFFECT: compound has improved activity in liver cells in vivo and is suitable for use in a method of treating a metabolic disorder or in a method of treating a cardiovascular disorder.
16 cl, 120 tbl, 112 ex
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