Show metadata Hide metadata

(19)

(11)

2 573 911

(13)

(51)

IPC

C07K14/58(2006-01-01)

C07K19/00(2006-01-01)

C12N5/10(2006-01-01)

C12Q1/68(2006-01-01)

A61K38/16(2006-01-01)

A61K47/48(2006-01-01)

A61K49/00(2006-01-01)

A61P19/00(2006-01-01)

(21) (22)

Application

2011152007/10, 2010-05-20

(24)

Start date

2010-05-20

(22)

Actual filing date

2010-05-20

(45)

Published

2016-01-27

(72)

Inventor

Vendt Dehniel Dzh.Aojagi-Skarber MikaLong ShinongVellar Mishel' KlodKastillo SiannaOkkhamafe Augustus O.Prajs Kristofer P.

(73)

Holder

Bajomarin Farmas'Jutikal Ink.

VERSIONS OF C-TYPE NATRIURETIC PEPTIDE Russian patent published in 2016 - IPC C07K14/58 C07K19/00 C12N5/10 C12Q1/68 A61K38/16 A61K47/48 A61K49/00 A61P19/00

Abstract RU 2573911 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to gene engineering, more specifically to producing C-type natriuretic peptide (CNP), and may be used in medicine. What is produced is a peptide having the structure PGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC (Pro-Gly-CNP37) applicable for treating degenerative bone pathologies in response to CNP.

EFFECT: as compared to native CNP, the invention enables increasing a plasma half-life ensured by a low ability to bind to endopeptidase and low affinity to NPR-C receptor with preserved CNP functionality.

17 cl, 83 dwg, 17 tbl, 19 ex

Similar patents RU2573911C2

Title	Year	Author	Number
USE OF OPTIONS OF NATRIURETIC PEPTIDE OF TYPE C FOR TREATMENT OF OSTEOARTHRITIS	2016	O'Neill, Charles, A. Oppeneer, Todd, M. Pinkstaff, Jason, K.	RU2759679C2
CNP PRODRUGS	2016	Sprogoe, Kennett Hersel, Ulrich Rau, Harald Wegge, Thomas Faltinger, Frank Cleemann, Felix Kaluza, Nora Bernhard, Ana Buba, Annette Woods, Tom	RU2824988C1
CONTROLLED RELEASE COMBINATION THERAPY WITH CNP AGONISTS	2017	Kholten-Andersen, Lars Miller Brajnkholt, Fibeke Sprogee, Kennett	RU2768747C2
NEW NPR-B AGONISTS	2010	Osterkamp Frank Khavlish Khajko Khummel Gerd Knaute Tobias Rajmer Ulf Rajneke Ulrikh Rikhter Uve Zimon Bernadett Shpeker Edgar Vojshnik Markus Khellberg Mark R.	RU2636738C2
APPLICATION OF VARIANTS OF NATRIURETIC PEPTIDE OF C-TYPE FOR TREATMENT OF SKELETAL DYSPLASIA	2016	Bullens, Sherry Bunting, Stuart Chou, Tianwei Okhamafe, Augustus, O. Price, Christopher, P. Wendt, Daniel, J. Yap, Clarence	RU2728567C2
NOVEL NRP-B AGONISTS	2010	Osterkamp Frank Khavlish Khajko Khummel' Gerd Knaute Tobias Rajmer Ul'F Rajneke Ul'Rikh Rikhter Uve Zimon Bernadett Shpeker Ehdgar Vojshnik Markus Khellberg Mark R.	RU2557290C2
APPLICATION OF C-TYPE NATRIURETIC PEPTIDE VARIANTS FOR THE TREATMENT OF SKELETAL DYSPLASIA	2016	Bullens, Sherry Bunting, Stuart Chou, Tianwei Okhamafe, Augustus, O. Price, Christopher, P. Wendt, Daniel, J. Yap, Clarence	RU2794515C2
ATRIAL NATRIURETIC PEPTIDE GRAFTED ANTIBODIES	2019	Mayer-Bartschmid, Anke Brockschnieder, Damian Geertz, Marcel Greven, Simone Hofmeister, Lucas, Hudson Joerissen, Hannah Mahlert, Christoph Marquardt, Tobias Mathar, Ilka Mondritzki, Thomas Noack, Claudia Tebbe, Jan Walsh, Stuart Weber, Ernst Wilmen, Andreas Wunder, Frank	RU2822433C2
AMIDE-BASED PRODRUGS OF GLUCAGON SUPERFAMILY PEPTIDES	2009	Dimarchi Richard D. Kou Bin'Bin'	RU2550696C2
HUMAN INTERLEUKIN-2 VARIANT OR ITS DERIVATIVE	2019	Chen, Lej Khu, Tsiyue Ge, Khu Lin, Yuan Van, Khunvej Ou, Yanchao Kun, Syanlin Lyao, Chen Chzhan, Lyanshan	RU2799437C2

RU 2 573 911 C2

Authors

Vendt Dehniel Dzh.

Aojagi-Skarber Mika

Long Shinong

Vellar Mishel' Klod

Kastillo Sianna

Okkhamafe Augustus O.

Prajs Kristofer P.

Dates

2016-01-27—Published

2010-05-20—Filed