C-TYPE NATRIURETIC PEPTIDE GRAFTED ANTIBODIES Russian patent published in 2024 - IPC C07K16/00 C07K14/58 C07K19/00 C12N15/62 C12N15/63 A61K38/22 A61K39/395 A61P7/00 A61P9/00 A61P13/12 A61P19/00 A61P27/02 

FIELD: biotechnology.

SUBSTANCE: invention discloses an antibody or a fragment thereof suitable as a natriuretic peptide receptor agonist. Antibody or fragment thereof comprises a heterologous amino acid sequence included inside a CDR portion, wherein said heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), a C-type natriuretic peptide (CNP) and a C-terminal linker sequence (Ctls). Also disclosed is a composition comprising an antibody or a fragment thereof, a nucleic acid encoding the antibody or a fragment thereof, a host cell containing said nucleic acid, a method of producing an antibody or a fragment thereof. Invention also relates to use of the antibody or its fragment in a method of treating cGMP and/or natriuretic peptide disorders.

EFFECT: invention provides obtaining agonists of the natriuretic peptide receptor with increased stability in serum as compared to wild-type natriuretic peptides of natural origin.

11 cl, 17 dwg, 11 tbl, 12 ex