INDANONE DERIVATIVE, ITS PHARMACEUTICALLY ACCEPTABLE SALT OR ENANTIOMER, METHOD FOR PRODUCING IT AND PHARMACEUTICAL COMPOSITION CONTAINING IT AND APPLICABLE FOR PREVENTING OR TREATING VIRAL DISEASE Russian patent published in 2016 - IPC C07D307/93 C07D407/12 C07D405/12 C07D417/12 C07D411/12 C07D405/04 C07D493/02 C07D209/94 C07D413/04 A61K31/343 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new indanone derivatives of formula I wherein the radicals A¹-A⁴, D, E, X and G¹-G⁴ have the values specified in the description, to their pharmaceutically acceptable salts or enantiomers, as well as to methods for producing them, and a pharmaceutical composition applicable for preventing and treating a viral disease and containing the above compounds as an active ingredient.

EFFECT: indanone derivatives possess the excellent inhibitory activity on picornaviruses, including Coxsackie viruses, entero-, echo-, polio- and rhinoviruses; it also possesses low cytotoxicity, and can be effective as an active ingredient of the pharmaceutical composition for preventing or treating a viral disease, including poliomyelitis, paralysis, acute haemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular fever, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, influenza, Coxsackie virus A disease, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

17 cl, 5 tbl, 307 ex