FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel 1,3-dioxoindene derivatives of structural formula 1 which can be applied for prevention or treatment of viral disease, caused by picornavirus. In formula 1 A1, A2, A3 and A4 is independently selected from the group, consisting of -H, C1-C10alkoxy, -NO2, -NR1R2 and -NR1(C=O)R2, where A4 does not exist, when Z3 represents nitrogen, and at least one of A1-A4 is not hydrogen; G represents -OH, -N3, C1-C10alkoxy, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1R2, -NR1(C=O)R2, -NR1(C=O)OR2, -NR1(C=O)-NR2R3, or
D1, D2, D3 and D4 is independently selected from the group, consisting of -H, halogen, -OH, C1-C10alkoxy, C1-C10 linear alkyl or alkyl with side chain, C6aryl, - (CH2)n-(C=O)OR1, -O(C=O)R1, -(C=O)R1, -NO2, -NR1(C=O)R2 and -SR1, or substituents D2 and D3 together can form six-membered ring, where ring, formed by substituents D2 and D3, can include one or several heteroatoms, and heteroatom represents N, and where D4 does not exist, when Z1 represents nitrogen, and D2 does not exist, when Z2 represents nitrogen; E represents -H, -OH, -OR1, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1(C=O)R2 or -SR1; each R1, R2 and R3 independently represents hydrogen, non-substituted or phenyl-substituted C1-C10 linear alkyl or alkyl with side chain, C1-C10alkoxy, non-substituted or phenyl-substituted C1-C10 linear alkenyl or alkenyl with side chain, C3cycoalkyl or non-substituted C6aryl; each X and Y independently represents hydrogen or oxygen; Z1, Z2 and Z3 represent carbon or nitrogen; n is equal to integer number from 1 to 10; and
stands for single or double bond. Invention also relates to method of obtaining claimed compounds and to pharmaceutical composition, which contains claimed compound.
EFFECT: obtaining compounds for prevention or treatment of viral disease.
16 cl, 5 tbl, 108 ex
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Authors
Dates
2015-10-27—Published
2012-06-18—Filed