FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel 1,3-dioxoindene derivatives of structural formula 1 
which can be applied for prevention or treatment of viral disease, caused by picornavirus. In formula 1 A1, A2, A3 and A4 is independently selected from the group, consisting of -H, C1-C10alkoxy, -NO2, -NR1R2 and -NR1(C=O)R2, where A4 does not exist, when Z3 represents nitrogen, and at least one of A1-A4 is not hydrogen; G represents -OH, -N3, C1-C10alkoxy, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1R2, -NR1(C=O)R2, -NR1(C=O)OR2, -NR1(C=O)-NR2R3, or 
D1, D2, D3 and D4 is independently selected from the group, consisting of -H, halogen, -OH, C1-C10alkoxy, C1-C10 linear alkyl or alkyl with side chain, C6aryl, - (CH2)n-(C=O)OR1, -O(C=O)R1, -(C=O)R1, -NO2, -NR1(C=O)R2 and -SR1, or substituents D2 and D3 together can form six-membered ring, where ring, formed by substituents D2 and D3, can include one or several heteroatoms, and heteroatom represents N, and where D4 does not exist, when Z1 represents nitrogen, and D2 does not exist, when Z2 represents nitrogen; E represents -H, -OH, -OR1, -O(C=O)R1, -O(C=O)OR1, -O(C=O)NR1R2, -NR1(C=O)R2 or -SR1; each R1, R2 and R3 independently represents hydrogen, non-substituted or phenyl-substituted C1-C10 linear alkyl or alkyl with side chain, C1-C10alkoxy, non-substituted or phenyl-substituted C1-C10 linear alkenyl or alkenyl with side chain, C3cycoalkyl or non-substituted C6aryl; each X and Y independently represents hydrogen or oxygen; Z1, Z2 and Z3 represent carbon or nitrogen; n is equal to integer number from 1 to 10; and 
stands for single or double bond. Invention also relates to method of obtaining claimed compounds and to pharmaceutical composition, which contains claimed compound.
EFFECT: obtaining compounds for prevention or treatment of viral disease.
16 cl, 5 tbl, 108 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INDANONE DERIVATIVE, ITS PHARMACEUTICALLY ACCEPTABLE SALT OR ENANTIOMER, METHOD FOR PRODUCING IT AND PHARMACEUTICAL COMPOSITION CONTAINING IT AND APPLICABLE FOR PREVENTING OR TREATING VIRAL DISEASE | 2012 |
|
RU2574591C2 |
| C-GLYCOSIDE DERIVATIVES CONTAINING A CONDENSED PHENYL RING, OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF PRODUCING SUCH AND A PHARMACEUTICAL COMPOSITION CONTAINING SUCH | 2017 |
|
RU2739024C2 |
| NOVEL TRICYCLIC DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVE | 2009 |
|
RU2470934C1 |
| COMPOUND CONTAINING OXADIAZOLE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | 2019 |
|
RU2789456C2 |
| NOVEL COMPOUNDS, ISOMERS THEREOF OR PHARMACUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUNDS | 2007 |
|
RU2448108C2 |
| TRIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF, USING TRIAZOLE COMPOUNDS AND METHOD FOR TREATMENT OF FUNGAL INFECTION | 2002 |
|
RU2276670C2 |
| SUBSTITUTED CHROMANS | 2015 |
|
RU2718060C2 |
| IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHODS FOR PRODUCTION THEREOF AND USE THEREOF | 2017 |
|
RU2725147C1 |
| SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | 2020 |
|
RU2815814C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, USING PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITION OF CATHEPSIN S ACTIVITY | 2001 |
|
RU2317988C2 |
