METHOD FOR OBTAINING PYRIMIDINE DERIVATIVES Russian patent published in 2016 - IPC C07D413/14 C07D413/04 A61K31/5377 A61P35/00 

Abstract RU 2576619 C2

FIELD: chemistry.

SUBSTANCE: invention relates to crystalline form of monohydrochloride salt of formula A compound in polymorphic form A, where said monohydrochloride salt has in diffraction of X-rays peak at diffraction angle 2θ 9.9±0.3° and 20.0±0.3°.

EFFECT: said crystalline form has low moisture-absorption in comparison with free base and monohydrate monochloride, which makes it possible to provide composition stability with low risk of chemical destruction.

4 cl, 10 tbl, 14 dwg, 16 ex

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RU 2 576 619 C2

Authors

Kalenni Dzhon Vinsent

De-La-Krus Merilin

Flubakher Ditmar

Gun Baotsin

Kapa Prasad Kotesvara

Karpinski Potr Kh.

Lju Khoj

Mishel Paskal

Mose Rasmus

Testa Maria Katerina

Vajkole Liladkhar Marlidkhar

Dates

2016-03-10Published

2011-09-29Filed