FIELD: chemistry.
SUBSTANCE: invention relates to crystalline forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate. The invention also relates to pharmaceutical composition for treatment of CNS diseases, associated with cognitive disorders, which contains crystalline form I or II, to method for obtaining pharmaceutical composition and to method for obtaining crystalline form I.
EFFECT: novel crystalline forms of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride in form of monohydrate, which are stable and have low hygroscopicity, have been obtained.
10 cl, 6 dwg, 9 tbl, 12 ex
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