NOVEL HETEROARENE ANTHRACENEDIONE-BASED G-QUADRUPLEX LIGANDS INHIBITING TUMOUR CELL GROWTH Russian patent published in 2014 - IPC C07D307/77 C07D333/50 A61K31/381 A61K31/343 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to linear heterocyclic anthracenedione derivatives containing guanidino(alkylamino) groups in positions 2, 4 and 11 and having the formula: as well as pharmacologically acceptable salts, where X independently denotes a heteroatom selected from O, S or an NH group which forms a five-member heteroarene condensed with an anthracenedione nucleus at bonds 2-3; n independently denotes a number from 2 to 4, which is equal to the number of spacer CH₂ groups which link amino groups in peri-positions of heteroarene anthracenedione with nitrogen atoms of guanidine group residues located in side chains; m independently denotes a number from 2 to 4, which is equal to the number of spacer CH₂ groups which link the nitrogen atom of a carboxamide group located at position 2 of the heterocyclic nucleus of heteroarene anthracenedione with the nitrogen atom of the guanidine group residue located in the side chain.

EFFECT: obtaining novel compounds which can be used in medicine for therapy of cancerous diseases.

2 tbl, 2 dwg, 8 ex