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2 581 831

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IPC

C07D498/04(2006-01-01)

A61K31/4985(2006-01-01)

A61P9/12(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2013110795/04, 2011-08-02

(24)

Start date

2011-08-02

(22)

Actual filing date

2011-08-02

(45)

Published

2016-04-20

(72)

Inventor

Sacurai Sergio LuizZaim Marcio HenriqueTouzarim Carlos Eduardo Da CostaKeppler Artur FranzDe Nucci Gilberto

(73)

Holder

Biolab Sanus Farmasjutika Ltda.

DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO[3,4-α]PYRAZINE-5,8-DIONE Russian patent published in 2016 - IPC C07D498/04 A61K31/4985 A61P9/12 A61P15/00

Abstract RU 2581831 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the derivatives of 6,7-dihydro-3H-oxazolo[3,4-α]pyrazine-5,8-dione of formula (I), where R¹ represents an indole group, R² represents methylene-3,4-dioxyphenyl group, R³ represents hydrogen, halogen, C_1-6 halogenalkyl, C_1-3 heteroalkyl or C_1-3 alkyl and R⁴ represents hydrogen, C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkinyl, C_1-6 halogenalkyl, C_3-8 cycloalkyl or C_3-8-cycloalkyl-C_1-3-alkyl, and their pharmaceutically acceptable salts. The invention also relates to the pharmaceutical composition, containing the compounds of formula ,

and to a method for obtaining the formula compound.

EFFECT: improvement of the properties of derivatives.

8 cl, 3 dwg, 2 ex

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RU 2 581 831 C2

Authors

Sacurai Sergio Luiz

Zaim Marcio Henrique

Touzarim Carlos Eduardo Da Costa

Keppler Artur Franz

De Nucci Gilberto

Dates

2016-04-20—Published

2011-08-02—Filed