FIELD: medicine.
SUBSTANCE: invention relates to medicine and represents pharmaceutical composition with sustained release for parenteral administration once a month. Composition is meant for hormonal replacement therapy in mammal females and contains oestradiol in amount of 0.25-1.0 mg in form of microparticles, where microparticles include oestradiol and cholesterol; progesterone in amount of 15 mg or 20 mg to 75 mg in the form of microparticles; surface-active agent; iso-osmotic agent; agent increasing viscosity; preserving agent and water filler. pH of composition ranges from 4 to 7. Microparticles have size from 1 to 100 mqm, and active substance is melted, sprayed, frozen and crystallised to obtain stable forms of active substances.
EFFECT: invention consists in application of composition for treating symptoms and discomfort associated with climacteric syndrome in females with uterus.
16 cl, 5 ex, 9 tbl, 3 dwg
