sGC STIMULATORS Russian patent published in 2016 - IPC C07D401/04 C07D401/14 C07D403/04 C07D405/14 C07D413/14 C07D417/04 C07D417/14 A61K31/427 A61K31/4439 A61K31/444 A61K31/497 A61K31/506 A61K31/5377 A61P7/02 A61P9/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula IA or IB or their pharmaceutically acceptable salts. The compounds of formula IA or IB possess sGC-stimulating activity. In formulas IA and IB , a circled B symbol means B ring, and B ring represents phenyl; n is equal to an integer specified in 0 to 1; each J^B is independently specified in halogen; X is specified in N or C-H; D ring represents a 6-merous ring having X in formula IA, or a 5-merous ring having Y in formula IB; each Y is independently specified in C-H, C, N, O or S and independently substituted by J^D when Y represents C or N; each of bonds between the two neighbouring atoms Y or between neighbouring Y and N in formula IB independently represents a single or double bond depending on whether Y is C, N, O or S, and D ring is aromatic; m is equal to an integer specified in 0 to 3; each J^D is a substituted on a halogen or nitrogen atom of the ring and independently specified in halogen, -C(O)N(R^D)₂, -N(R^D)₂, -N(R^d)C(O)R^D, -N(R^d)C(O)OR^D, a 4-8-merous heterocyclic ring, wherein each specified 4-8-merous heterocyclic ring contains 1 to 2 heteroatoms independently specified in O, N or S; R^C is specified in halogen, -CN, C_1-6alkyl or C ring. The invention also refers to individual compounds and a pharmaceutical composition containing the compound of the invention or its pharmaceutically acceptable salt in an effective amount.

EFFECT: produced are the new compounds of formula IA or IB possessing sGC-stimulating activity.

58 cl, 6 tbl, 12 ex