TRICYCLIC COMPOUNDS AS INHIBITORS OF IMMUNOSUPPRESSION MEDIATED BY TRYPTOPHAN METABOLIZATION Russian patent published in 2018 - IPC C07D487/04 A61K31/4188 A61K31/4192 A61K31/4196 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) wherein n is 0; bond α is a single bond; ring A is an aromatic ring, where i) V and X represent N, W and Z represent CH and Y represent C; or ii) V, Y and Z represent N, W represents CH and X represents C; or iii) V, W and Y represent N, X represents C and Z represents CH; R² represents -CH₂-R^A, R^A represents -C(O)R³ or -C(OR^B)(R³)(R^C), R^B represents a hydrogen atom; each R³ represents C_3-8-cycloalkyl or 6-membered heterocyclyl containing one nitrogen atom as a heteroatom, C_3-8cycloalkyl is optionally substituted with two R³¹ groups; 6-membered heterocyclyl is optionally substituted by one R³¹ group; each R³¹ independently represents a halogen atom or -C(O)N(R)₂, and R^C is a hydrogen atom; and each R independently represents a hydrogen atom or R¹⁰, R¹⁰ is phenyl, optionally substituted with C_1-6-alkyl group. Invention also relates to individual compounds and to a pharmaceutical composition.

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EFFECT: novel compounds of formula (I) having IDO/TDO inhibitory activity are obtained.

18 cl, 4 dwg, 19 ex