FIELD: medicine.
SUBSTANCE: invention may be used for creation of new effective agent to increase heart resistance to arrythmogenic action of ischaemia and reperfusion. Application is proposed of kappa-opioid receptor agonist ICI-199441 (2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride) as an agent which reduces probability of arrhythmias at coronary occlusion and reperfusion.
EFFECT: antiarrhythmic effect is developed in dose, which in 10 times less than dose of U-50488 required to increase heart resistance to arrhythmogenic action of ischaemia and reperfusion.
1 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-ARRHYTHMIC AGENT | 2004 |
|
RU2260442C1 |
| ANTI-ARRHYTHMIC AGENT | 2003 |
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|
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| ETHYL-3-(2,2-DIMETHYL-2-ETHYLHYDRAZONIUM)PROPIONATE-IODIDE WITH ANTI-ARRHYTHMIC ACTIVITY | 0 |
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SU1680693A1 |
