ANTIBODY AGAINST LIPOARABINOMANNAN AND IMMUNOASSAY OF INFECTIONS CAUSED BY ACID-FAST BACILLI, USING ANTIBODY Russian patent published in 2016 - IPC C07K16/12 C12N15/02 C12M1/34 G01N33/569 G01N33/577 C12P21/08 G01N33/53 C12Q1/02 C12N15/09 

FIELD: biochemistry.

SUBSTANCE: described is monoclonal antibody which specifically binds to lipoarabinomannan of acid-fast bacilli, particularly with lipoarabinomannan of tuberculosis bacilli. Described antibody is monoclonal antibody containing variable heavy and light chain variable region, connected through linker. Variable heavy chain contains CDR1-CDR3 shown in (a)-(c), and light chain contains CDR1-CDR3 shown in (d)-(f):

(a) heavy chain CDR1, consisting of amino acid sequence SEQ ID No:1,

(b) heavy chain CDR2 consisting of amino acid sequence SEQ ID No:2,

(c) heavy chain CDR3 consisting of amino acid sequence SEQ ID No:3,

(d) light chain CDR1, consisting of amino acid sequence SEQ ID No:4,

(e) light chain CDR2 consisting of amino acid sequence SEQ ID No:5, and

(f) light chain CDR3 consisting of amino acid sequence SEQ ID No:6. Invention also describes reagent kit and device containing described antibody.

EFFECT: invention extends range of products for detecting of mycobacteria.

18 cl, 19 dwg, 5 tbl, 12 ex