FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions refers to monoclonal antibodies directed to epitopes detected within lipoarabinomannan (LAM) for diagnosis and treatment of infections caused by Mycobacterium tuberculosis. Disclosed is a human monoclonal antibody to lipoarabinomannan (to LAM) or its antigen-binding portion, which specifically bind to LAM epitope, containing an Ara4 structure, an Ara6 structure or a combination thereof, wherein the LAM antibody comprises a light chain variable region CDR1 characterized by at least 80 % identity with SEQ ID NO: 1 or antigen fragments thereof, CDR2 of the light chain variable region, characterized by at least 80 % identity with SEQ ID NO: 2 or its antigen fragments, light chain variable region CDR3, characterized by at least 80 % identity with SEQ ID NO: 3 or SEQ ID NO: 26 or their antigen fragments, heavy chain variable region CDR1, characterized by at least 80 % identity with SEQ ID NO: 4 or its antigen fragments, heavy variable domain variable region CDR2, characterized by at least 80 % identity with SEQ ID NO: 5 or its antigen fragments, and CDR3 of heavy chain variable region, characterized by at least 80 % identity with SEQ ID NO: 6 or SEQ ID NO: 23 or their antigen fragments. Also disclosed is a kit for detecting at least one epitope of LAM, a method for diagnosing active tuberculosis infection in an individual and a method of treating tuberculosis infection in an individual.
EFFECT: group of inventions provides effective treatment and diagnosis of tuberculosis infection.
15 cl, 32 dwg, 4 tbl, 2 ex
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Authors
Dates
2020-09-18—Published
2017-02-01—Filed