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2 589 696

(13)

(51)

IPC

A61K31/436(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012148133/15, 2011-04-12

(24)

Start date

2011-04-12

(22)

Actual filing date

2011-04-12

(45)

Published

2016-07-10

(72)

Inventor

Borland MariyaBrejn Kristofer TomasDoshi ShivangKim SunkiuMa TszyangoMerti DzhoshChzhan Khun

(73)

Holder

Novartis Ag

COMBINATION INCLUDING CYCLIN-DEPENDENT KINASE 4 INHIBITOR OR CYCLIN-DEPENDENT KINASE 6 INHIBITOR (CDK4/6) AND mTOR INHIBITOR FOR TREATING CANCER Russian patent published in 2016 - IPC A61K31/436 A61K31/519 A61P35/00

Abstract RU 2589696 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents combination for treating cancer, including first agent, which is cyclino-dependent kinase inhibitor 4 or cyclino-dependent kinase 6 (CDK4/6), which is dimethylamide 7-cyclopenthyl-2-(5-piperazine-1-ilpiridine-2-yl-amino)-7H-pyrrolo[2,3-d]pyrimidin-6-carboxylic acid or its pharmaceutically acceptable salt and second agent, which is mTOR inhibitor, everolimus.

EFFECT: invention provides synergetic effect of declared combination.

11 cl, 11 ex, 18 dwg

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RU 2 589 696 C2

Authors

Borland Mariya

Brejn Kristofer Tomas

Doshi Shivang

Kim Sunkiu

Ma Tszyango

Merti Dzhosh

Chzhan Khun

Dates

2016-07-10—Published

2011-04-12—Filed