CERTAIN PROTEIN KINASE INHIBITORS Russian patent published in 2020 - IPC C07D495/04 A61K31/519 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (II)

(II)

or a pharmaceutically acceptable salt thereof, in which Q denotes pyridinyl, R¹ is selected from piperazinyl and piperidinyl, which is substituted with at least one substitute, such as one, two, three or four substituents independently selected from R^X, R² denotes C_3-10 cycloalkyl, R³ is selected from hydrogen and C_1-6 alkyl, R⁴ is selected from hydrogen and C_1-6 alkyl, R⁵ is independently selected from hydrogen and halogen, each R^X is independently selected from piperazinyl, piperidinyl and morpholinyl, which is unsubstituted or substituted with at least one substitute, such as one, two, three or four substituents, independently selected from R^Y, each R^Y is independently selected from halogen, CN and C_1-6 alkyl, m is selected from 0, 1, 2 and 3, which are inhibitors of CDK4/6 kinase activity and can be used for treating hyperproliferative diseases, such as cancer and inflammation.

EFFECT: some inhibitors of protein kinase are proposed.

15 cl, 4 tbl, 8 ex