POLYCYCLIC SUBSTITUTED PYRAZOLE KINASE ACTIVITY INHIBITORS AND USE THEREOF Russian patent published in 2018 - IPC C07D495/04 C07D491/48 C07D487/04 C07D471/04 A61K31/519 A61K31/496 A61K31/5377 A01N43/90 A61P25/00 A61P29/00 A61P35/00 A01P3/00 

Abstract RU 2655921 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to the field of medical chemistry and in particular relates to 4-(substituted five-membered heterocyclic pyrimidine/pyridine) amino-1H-3-pyrazolecarboxamide derivatives of formula (I), in which the radicals and symbols are defined in the claims. Compounds of formula (I) are protein kinase inhibitors. (I).

EFFECT: invention also relates to a pharmaceutical composition comprising said compounds, and to their use in medicine as an antitumor agent.

12 cl, 1 dwg, 7 tbl, 58 ex

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RU 2 655 921 C2

Authors

Lu Tao

Van Yue

Chen Yadun

Lu I.

Van Chzhanvej

Tszin Tsyaomej

Yan Taotao

Lin Gou

Go Tsinlun

Chzhao Li

Dates

2018-05-30Published

2014-01-07Filed