SYSTEMS AND METHODS FOR DELIVERY OF BIOACTIVE PRODUCTS USING TRANSPORT SEQUENCES DERIVED FROM BACTERIAL TOXIN Russian patent published in 2016 - IPC C07K19/00 C07K14/28 A61K47/42 A61K38/00

Abstract RU 2593715 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to production of non-toxic mutant forms of Vibrio cholera Cholix gene (ntCholix), and can be used in medicine. Variant of Cholix is produced, which is truncated at amino acid A³⁸⁶ (Cholix³⁸⁶) or with a removable residue Glu⁵⁸¹. Obtained non-toxic variant of Cholix is linked with therapeutic load, which can be a macromolecule, small molecule, siRNA, PNA miRNA, DNA, plasmid and an antisense molecule.

EFFECT: invention provides delivery of therapeutic load through polarised epithelial cells, including intestine, in direction from apical to basolateral surface of monolayers of cells without injections.

11 cl, 2 dwg, 3 ex

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RU 2 593 715 C2

Authors

Mrsny Randall J.

Mahmood Tahir

Dates

2016-08-10—Published

2011-09-15—Filed