FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry. Method of inhibiting replication of human immunodeficiency virus (HIV), involving treatment of mammalian cells with agent selected from group of peptides, interfering RNA or anti-sense oligonucleotide destructive structure proteins vimentin and/or keratin-10 of cytoskeletal intermediate filaments (IF) in mammal cell. Invention also relates to use of said agent for preparing drug for treating of HIV-infection. Besides, there are presented pharmaceutical compositions for treating of HIV-infection, containing said agent.
EFFECT: invention increases HIV replication inhibition.
10 cl, 11 dwg, 2 tbl, 12 ex
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