FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology and molecular biology. Disclosed is an adenoviral genome for protecting adenovirus from neutralizing antibodies, characterized by that it contains a sequence coding an albumin-binding site inserted in the coding region of hypervariable portion 1 (HVR1) of hexone protein, which leads to expression of the fused protein, containing a hexone protein and an albumin-binding site, and wherein the albumin-binding portion is located on the outer surface of the hexone protein when the hexone protein assembly takes place in the adenoviral capsid.
EFFECT: invention can be used in medicine in preventing and/or treating cancer.
33 cl, 12 dwg, 1 tbl, 1 ex
| Title |
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