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(19)

RU

(11)

2 598 709

(13)

C2

(51)

IPC

C12N15/113(2010-01-01)

A61K31/7088(2006-01-01)

A61P3/08(2006-01-01)

(21) (22)

Application

2014115215/10, 2012-09-20

(24)

Start date

2012-09-20

(22)

Actual filing date

2012-09-20

(45)

Published

2016-09-27

(72)

Inventor

Frejer Syuzan M.Bkhanot Sanzhaj

(73)

Holder

Ajsis Farmasyutikals, Ink.

ANTISENSE MODULATION OF GCGR EXPRESSION Russian patent published in 2016 - IPC C12N15/113 A61K31/7088 A61P3/08 

Abstract RU 2598709 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to biotechnology. Provided herein are compounds for inhibiting expression of glucagon receptor (GCGR) consisting of consisting of 12 to 30 linked nucleosides, and compositions for reducing expression of GCGR, methods of treating metabolic disease, decreasing and delaying blood glucose levels, preventing disease associated with GCGR, use of the compounds to prepare a drug.

EFFECT: compounds, compositions and methods may be used in medicine for expression of mRNA and GCGR protein in treating or preventing diseases associated with metabolic disorders.

58 cl, 31 tbl, 19 ex

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RU 2 598 709 C2

Authors

Frejer Syuzan M.

Bkhanot Sanzhaj

Dates

2016-09-27—Published

2012-09-20—Filed

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