FIELD: pharmaceuticals.
SUBSTANCE: invention refers to compounds for treating metabolic diseases and can be used in medicine. Disclosed is a compound comprising a single-chain modified oligonucleotide and a conjugating group, or a pharmaceutically acceptable salt thereof, wherein the conjugating group contains
,
where the cleavable fragment (CM) is a bond or a group which can be split under physiological conditions; modified oligonucleotide has formula: Ges Ges Tes Tds mCds mCds mCds Gds Ads Gds Gds Tds Gds mCes mCes mCes Ae, where A = adenine, mC = 5'-methylcytosine, G = guanine, T = thymine, e = 2'-O-methoxyethyl modified nucleoside, d = 2'-deoxynucleoside and s = thiophosphate internucleoside linkage; and the conjugating group is bound to the modified oligonucleotide by 5'-end of modified oligonucleotide.
EFFECT: novel compounds and compositions based thereon for treating metabolic diseases are disclosed.
5 cl, 113 ex, 108 tbl, list of sequences
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