FIELD: pharmaceutics.
SUBSTANCE: invention relates to compounds of formula I, their stereoisomers and pharmaceutically acceptable salts thereof, in which R1, R2, R3, R4 and R10 assume values given in the patent claim. Declared compounds are inhibitors of kinase tyrosine kinases PIM-1, and/or PIM-2, and/or PIM-3 and can be used in treating diseases mediated by said kinase. Invention also relates to a pharmaceutical composition based on them, methods of producing the declared compounds and an intermediate compound used in production of the declared compounds.
EFFECT: disclosed are compounds of Formula I, their stereoisomers and pharmaceutically acceptable salts.
56 cl, 6 tbl, 11 ex biological researches (A-K), 6 receptions of, 328 ex
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