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2 610 262

(13)

(51)

IPC

C07D401/06(2006-01-01)

C07D401/14(2006-01-01)

C07D215/48(2006-01-01)

A61K31/4725(2006-01-01)

A61P25/20(2006-01-01)

A61P25/28(2006-01-01)

A61P25/04(2006-01-01)

(21) (22)

Application

2014122335, 2012-10-26

(24)

Start date

2012-10-26

(22)

Actual filing date

2012-10-26

(45)

Published

2017-02-08

(72)

Inventor

Bungard Kristofer DzhejmsKonverso AntonellaDe Leon PabloKhanni BarbaraKharting Timoti DzhonManikovski Dzhess DzhozefMenli Piter Dzh.Mejssner RobertMyn ChzhaoyanPerkins Dzhejms Dzh.Radd Majkl T.Shu Yukhen

(73)

Holder

Merk Sharp I Doum Korp.

QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND USE THEREOF Russian patent published in 2017 - IPC C07D401/06 C07D401/14 C07D215/48 A61K31/4725 A61P25/20 A61P25/28 A61P25/04

Abstract RU 2610262 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to organic chemistry, namely, to quinoline carboxamide derivatives of following structures. Invention also relates to pharmaceutical composition based on one of said compounds, use of said compounds for treating diseases or disorders mediated by mGluR₂, such as Alzheimer's disease, cognitive disorder, schizophrenia, mood disorders, painful disorders, and sleep disorders.

EFFECT: novel quinoline carboxamide derivatives with useful biological properties.

25 cl, 8 tbl, 310 ex

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RU 2 610 262 C2

Authors

Bungard Kristofer Dzhejms

Konverso Antonella

De Leon Pablo

Khanni Barbara

Kharting Timoti Dzhon

Manikovski Dzhess Dzhozef

Menli Piter Dzh.

Mejssner Robert

Myn Chzhaoyan

Perkins Dzhejms Dzh.

Radd Majkl T.

Shu Yukhen

Dates

2017-02-08—Published

2012-10-26—Filed