[1,3]OXAZINES Russian patent published in 2016 - IPC C07D413/12 A61K31/5355 A61P25/28 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I or its pharmaceutically acceptable salts thereof. Compound of formula (I) possess the properties of BACE1 and/or BACE2. In formula I:

R¹ represents a 6-member heteroaryl containing 2 heteroatoms selected from N substituted with a substitute C_2-6-alkynyl-C-_1-6-alkoxy; R² is a halogen atom; R³ is C_1-6-alkyl; R⁴ is selected from a halogen atom; R⁵ is selected from a halogen atom; R⁶ is selected from a hydrogen atom, and R⁷ is selected from a hydrogen atom. Invention also relates to a tritium labelled compound of formula Ia, ¹¹C-labelled compound of formula Ia', structural formulae are given in the claim, to a method for diagnostic imaging BACE1 enzyme, use of compounds when preparing the composition for diagnostic imaging BACE1, to a pharmaceutical composition, use of compounds in preparing a drug, to a method of inhibiting activity BACE1 and/or BACE2.

EFFECT: obtaining novel compounds of formula I possessing the properties of BACE1 and/or BACE2.

33 cl, 7 tbl, 9 ex