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2 637 948

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

C07D498/04(2006-01-01)

C07D498/20(2006-01-01)

A61K31/506(2006-01-01)

A61K31/5383(2006-01-01)

A61P25/16(2006-01-01)

(21) (22)

Application

2014147382, 2013-04-30

(24)

Start date

2013-04-30

(22)

Actual filing date

2013-04-30

(45)

Published

2017-12-08

(72)

Inventor

Bejker-Glenn CharlzChan Brajan K.Dotson DzhennaferEstrada EntoniKheffron TimotiLissikatos DzhozefSvini Zakari Kevin

(73)

Holder

Genentech, Inc.

PYRAZOLAMINOPIRIMIDINE DERIVATIVES AS LEUCINE-REPEATING KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON DISEASE Russian patent published in 2017 - IPC C07D471/04 C07D487/04 C07D498/04 C07D498/20 A61K31/506 A61K31/5383 A61P25/16

Abstract RU 2637948 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the formula or to their pharmaceutically acceptable salts, wherein X, R¹, R², R³ and A are as defined in the claims. The compounds of formula (I) are modulators of leucine-repeating kinase 2 (LRRK2) modulators.

EFFECT: application fortreatment of diseases associated with the LRRK2 receptor, such as Parkinson's disease.

20 cl, 2 tbl, 53 ex

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RU 2 637 948 C2

Authors

Bejker-Glenn Charlz

Chan Brajan K.

Dotson Dzhennafer

Estrada Entoni

Kheffron Timoti

Lissikatos Dzhozef

Svini Zakari Kevin

Dates

2017-12-08—Published

2013-04-30—Filed