FIELD: chemistry.
SUBSTANCE: invention relates to novel crystalline salts which is useful as an antitumor agent: methanesulfonate 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranozil)cytosine showing characteristic peaks at diffraction angles in powder X-ray diffractometry at diffraction angles (2θ) 19.8, 21.8, 27.5, 28.4 and 29.9 degrees and hydrochloride 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranozil)cytosine with characteristic peaks in powder x-ray powder diffractometry at diffraction angles (2θ) 9.2, 14.7, 15.7, 22.9 and 27.3 degrees.
EFFECT: there are proposed novel crystalline forms with excellent antitumor activity, water-solubility, flowability, tableting, not hygroscopic, environmentally friendly.
5 cl, 5 ex, 6 tbl, 4 dwg
| Title | Year | Author | Number |
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