FIELD: pharmaceutics.
SUBSTANCE: invention relates to crystals (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyl tetrahydro-2H-pyran-3-yl]-6ʺ-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2ʺ-oxo-1ʺ,2ʺ-dihydrodispiro[cyclohexane-1,2'-pyrrolidin-3'3ʺ-indole]-5'-carboxamide, which is represented by the following formula (1), or salts thereof, such as hydrochloride, methanesulfonate, benzenesulfonate and toluenesulfonate, which inhibit Mdm2 and have anti-tumor activity, as well as to a drug on their basis.
Formula 1 
.
EFFECT: invention has anti-tumor activity.
18 cl, 24 dwg, 8 tbl, 2 ex
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