FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to pharmaceutical industry, in particular, to a pharmaceutical solid molecular dispersion, with ratio fesoterodine hydrogen fumarate: alkyl hydroxyalkylcellulose ether or hydroxyalkylcellulose ether, or an ester of either thereof, or a mixture of any two or more thereof, ranging from 3:97-12:88 wt%, method of production thereof, as well as to a pharmaceutical inert granule or particle, which is a core, which is coated with said dispersion and a pharmaceutical composition, including in form of tablets containing such granules. In one embodiment fesoterodine hydrogen fumarate is stabilised in dispersion in a form, which not correspond to its crystalline or amorphous form.
EFFECT: group of inventions provides high chemical stability of compositions containing fesoterodine hydrogen fumarate.
24 cl, 12 ex, 27 tbl, 19 dwg
