FIELD: pharmaceutics.
SUBSTANCE: invention relates to a novel salt - dichloroacetate {3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazole-1-yl]-1-ethylsulfonyl-azetidine-3-yl}-acetonitrile, which is Janus kinase inhibitor (JAK), wherein it exhibits selective action on JAK3. Compounds can be used for treating autoimmune disease or disorder, such as rheumatoid arthritis, psoriatic arthritis or juvenile arthritis. {3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazole-1-yl]-1-ethylsulfonyl-azetidine-3-yl}-acetonitrile dichloroacetate has formula (1):
.
Compound of formula 1 can be obtained by reaction of {3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazole-1-yl]-1-ethylsulfonyl-azetidine-3-yl}-acetonitrile with dichloroacetic acid.
EFFECT: invention also relates to pharmaceutical composition effective for treating JAK-related diseases in form of tablets, capsules or injections, placed in pharmaceutically acceptable pack, and method of treating.
9 cl, 2 tbl, 6 ex
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Year |
Author |
Number |
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|
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