FIELD: chemistry.
SUBSTANCE: group of inventions relates to chemical-pharmaceutical industry, medicine and pharmacology and includes 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(3-(methylthio)propanoyl)azetidine-3-yl)acetonitrile, pharmaceutically acceptable salts thereof, as well as a pharmaceutical composition and a drug containing same, and use for preparing a drug for treating autoimmune diseases by inhibition of Janus kinase.
EFFECT: improved activity and selectivity of 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(3-(methylthio)propanoyl)azetidin-3-yl)acetonitrile compared to baricitinib with respect to inhibition of JAK enzymes.
11 cl, 2 dwg, 3 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL PYRROLOPYRIMIDINE DERIVATIVES | 2024 |
|
RU2837215C1 |
| NOVEL PYRROLOPYRIMIDINE DERIVATIVES | 2024 |
|
RU2837533C1 |
| NOVEL PYRROLOPYRIMIDINE DERIVATIVES | 2024 |
|
RU2837548C1 |
| NOVEL PYRROLOPYRIMIDINE DERIVATIVES | 2024 |
|
RU2837216C1 |
| NOVEL PYRROLOPYRIMIDINE DERIVATIVES | 2024 |
|
RU2837221C1 |
| METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE | 2024 |
|
RU2835441C1 |
| METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE | 2024 |
|
RU2835443C1 |
| METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE | 2024 |
|
RU2835445C1 |
| {3-[(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)AZOLYL]AZETIDIN-3-YL} ACETONITRILES AS JANUS KINASE INHIBITORS | 2015 |
|
RU2601410C1 |
| TREATMENT OF HYDRADENITIS WITH JAK INHIBITORS | 2020 |
|
RU2805595C1 |
