FIELD: chemistry.
SUBSTANCE: invention relates to a novel compound of formula I-1, characterised by effects of thrombolysis, accepting free radicals and directed action on thrombus. Compound is a three-component conjugate formed by conjugation of thrombolytic oligopeptide, free radical acceptor and a peptide with directed action on thromb/antithrombotic oligopeptide by binder link.
EFFECT: present invention also relates to a pharmaceutical composition containing compounds, wherein compounds form a nanospherical structure.
13 cl, 40 dwg, 21 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING, AND SYNTHESIS, NANO-STRUCTURE AND USE THEREOF | 2014 |
|
RU2660901C2 |
| PEPTIDE AND A METHOD OF ITS SYNTHESIS | 1994 |
|
RU2067000C1 |
| PEPTIDES WITH ANTICOAGULANT, FIBRINOLYTIC, ANTI-PLATELET AND ANTI-THROMBOSIS ACTIVITY | 2005 |
|
RU2286166C1 |
| PEPTIDE POSSESSING ANTI-COAGULANT, FIBRIN-DEPOLYMERIZATION, ANTI-THROMBOSIS AND FIBRINOLYTIC ACTIVITIES | 2005 |
|
RU2288736C1 |
| HEPTAPEPTIDE POSSESSING PROPERTIES OF PSYCHOSTIMULATOR OF PROLONGED ACTION WITH IMMUNOTROPIC ACTIVITY | 1983 |
|
RU1124544C |
| METHOD OF PREPARING POLYPEPTIDES | 0 |
|
SU904518A3 |
| RGD-CONTAINING PEPTIDES | 2001 |
|
RU2214416C2 |
| ANTIBODY AND DRUG CONJUGATES (ADC) AND ANTIBODY AND PRODRUG CONJUGATES (APDC) CONTAINING ENZYMATICALLY CLEAVABLE GROUPS | 2016 |
|
RU2751512C2 |
| METHOD OF PRODUCING PEPTIDES | 0 |
|
SU1598881A3 |
| DERIVATIVES OF HEMIN AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD FOR PREPARING, APPLICATION AND PHARMACEUTICAL COMPOSITION | 2002 |
|
RU2238950C2 |
