FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Present invention relates to binding proteins, specific to VEGF-A, in particular to recombinant binding proteins, containing polyethyleneglycol fragment and binding domain, which inhibit binding of VEGF-Axxx with VEGFR-2. Examples of such recombinant binding proteins are proteins, which contain anchored binding domain, repeated with desired specificity, and polyethyleneglycol fragment.
EFFECT: binding proteins are effective in treating cancer and other pathological states, for example eye diseases, such as age related macular degeneration.
18 cl, 8 dwg, 5 ex
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