FIELD: biotechnology.
SUBSTANCE: options of an anti-VEGF antibody, conjugates, fused proteins and compositions, including the specified antibodies, are proposed, as well as their use for the treatment of disorders related to pathological angiogenesis. In addition, the invention relates to polynucleotide encoding the anti-VEGF antibody, an expression vector and a host cell including the specified polynucleotide, as well as to their use in a method for producing the antibody according to the invention.
EFFECT: invention provides for the production of antibodies with increased affinity of binding to VEGF and improved stability.
144 cl, 45 dwg, 20 tbl, 13 ex
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