FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Conjugate of growth hormone (GH) is disclosed, containing GH with single mutation of Cys addition, selected from A98C, N99C, L101C and V102C, and albumin-binding radical, attached through hydrophilic spacer to sulphur atom of this single Cys. Conjugate of growth hormone with specific alternative hydrophilic spacers for attachment of albumin-binding radical is also disclosed.
EFFECT: this invention can be used in production of growth hormone conjugates with increased stability and longer half-life in vivo.
14 cl, 2 dwg, 6 tbl, 51 ex
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