FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to pharmacology, namely to conjugated proteins, in particular, but not exclusively, to factors of blood coagulation, to methods of obtaining said conjugates, which include stages of interaction of protein or glycoprotein with water-insoluble albumin-binding substance in presence of cyclodextrin molecule, as well as to pharmaceutical compositions, containing said conjugates, and to application of conjugates in manufacturing medication for therapy.
EFFECT: group of inventions ensures increase of bioavailability, period of half-life in vivo, increased resistance to proteases, reduction of immunogenicity.
21 cl, 51 ex
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