BORON-CONTAINING SMALL MOLECULES Russian patent published in 2017 - IPC C07F5/02 A61K31/69 A61P31/10 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to boron-containing compounds, namely to the compound which represents 5-fluoro-1,3-dihydro-1-hydroxy-3-methyl-2,1-benzoxaborole, 6-fluoro-1-hydroxy-1,2,3,4-tetrahydro-2,1-benzoxaborine, 5-cyano-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 1,3-dihydro-1-hydroxy-5-methyl-2,1-benzoxaborole, 1,3-dihydro-1-hydroxy-5-hydroxymethyl-2,1-benzoxaborole, 7-hydroxy-2,1-oxaborolano[5,4-cl]pyridine, 3-benzyl-1,3-dihydro-1-hydroxy-3-methyl-2,1-benzoxaborole, 3-benzyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 6-phenoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 5-(N-methyl-N-phenyl sulfanilamide)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 6-(4-methoxyphenyl sulfonyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 6-(4- methoxyphenyl sulfonyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole or 4-(4-cyano-phenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole or its pharmaceutically acceptable salt. Invention also discloses the compound and its pharmaceutically acceptable salt of formula (IIb), pharmaceutical compositions, use of compounds and pharmaceutical compositions.

EFFECT: invention enables to obtain compounds applicable for treating or preventing infection.

84 cl, 12 dwg, 6 tbl, 20 ex