HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE Russian patent published in 2018 - IPC C07D413/06 C07D417/06 C07D417/14 C07D471/04 C07D487/04 A61K31/423 A61K31/428 A61K31/4427 A61K31/52 A61K31/5377 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound having the formula VIIb:

VIIb,

wherein each of R¹ and R² is hydrogen; R³ is hydrogen or C_1-6alkyl; each Q¹ independently is halogen, oxo, C_1-6alkyl, -R^uOR^x, -R^uSR^x, =NOR^d, where alkyl groups are optionally substituted with one hydroxyl; Y is -(CR⁵R⁶)_q-; Z is O or S; each W is independently CR⁸ or N; W¹ is N or C; W² is N or C; W⁴ is N; W⁵ is N or CR¹³; R¹³ is hydrogen or Q²; each of Q⁵ and Q⁶ independently represents hydrogen, halogen, cyano, C_1-6alkyl, halogen C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, C_3-7cycloalkyl, C_3-7cycloalkenyl, 5-6 membered heteroaryl with one to four nitrogen atoms, 6-membered heterocyclyl with one to two heteroatoms independently selected from a nitrogen atom and oxygen, 6-membered partially unsaturated heterocyclyl with one heteroatom selected from a nitrogen atom and oxygen, (6-membered heterocyclyl with two heteroatoms independently selected from nitrogen atom and oxygen)-C_1-6alkyl, -R^uOR^x, -R^uN(R^y)(R^z), -R^uSR^x, -R^uC(J)R^x, -R^uC(J)OR^x, -R^uC(J)N(R^y)(R^z), -R^uC(J)C_1-6alkyl-N(R^y)(R^z), -R^uC(J)N(R^y)OR^x, -R^uS(O)_tR^w, -R^uN(R^x)C(J)R^x or -C(=NOR^x)R^x, where the alkyl, alkenyl, alkynyl, heteroaryl and heterocyclyl groups are optionally substituted with one to three Q groups⁸; J is O or NR^x; each t is 2; and q is 0 or 1; values of other radicals are given in the patent claim. Invention also relates to pharmaceutical composition, to method for treating a disease and to a method for modulating a kinase CSF1R, FLT3, KIT and/or PDGFRβ.

EFFECT: technical result: new compounds of formula VIIb, which are kinase modulators CSF1R, FLT3, KIT and/or PDGFRβ.

20 cl, 6 dwg, 4 tbl, 242 ex