FIELD: biotechnologies.
SUBSTANCE: group of inventions relates to biotechnology. Disclosed is method of producing a composition containing purified recombinant human N-acetylgalactosamine-6-sulphatase (GALNS) enzyme, where GALNS enzyme includes amino acid sequence identical to at least by 95 % to 27–522 amino acids of SEQ ID NO: 4 sequence. Disclosed are compositions containing effective amount of human recombinant enzyme N-acetylgalactosamine-6-sulphatase (GALNS).
EFFECT: group of inventions enables to obtain large amount of human GALNS enzyme, 98 % of which is presented in form of precursor, and can be used in preparing drug for treating of type IVa (MPS IVa) mucopolysaccharidosis or A type Morquio syndrome.
9 cl, 19 dwg, 19 tbl, 14 ex
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