PRODUCTION OF HIGH-MANNOSE PROTEINS IN PLANT CULTURES Russian patent published in 2014 - IPC A61K38/47 C12N9/36 C12N15/56 

Abstract RU 2535342 C2

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry and provides a pharmaceutical composition for treating Gaucher's disease, which contains as an active ingredient lyophilised plant cells which express recombinant human glucocerebrosidase, a pharmaceutically acceptable carrier, where said pharmaceutical composition is intended for oral administration and where said human glucocerebrosidase has high-mannose glycosylation.

EFFECT: invention enables to obtain an effective pharmaceutical composition for treating Gaucher's disease with high enzyme biological activity owing to high-mannose glycosylation thereof.

16 cl, 21 dwg, 3 tbl, 6 ex

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RU 2 535 342 C2

Authors

Shaaltiel Jozef

Baum Gideon

Bartfeld Dehniel

Khashmueli Sharon

Levkovich Ajjala

Dates

2014-12-10Published

2009-12-23Filed