FIELD: pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and medicine. Method of producing dalfampridin pellets is disclosed, characterized by preparing intra-granulated mixture by screening dalfampridin together with hydroxypropyl methyl cellulose with viscosity of 80–120 MPA˙s, mixing with microcrystalline cellulose with particle size of 50–90 mcm and aerosil, compaction, mixing with magnesium stearate, it is followed by granulation of mixture by rolling, extra-granulated mixture is added to obtained granules consisting of microcrystalline cellulose with particle size of 50–90 mcm and aerosil, mixed to homogeneous state, magnesium stearate is added, tablets are pressed and coated with their shell by spraying water solution of white Opadraja till tablet weight increases by 1.0–3.0 %.
EFFECT: obtained solid shape has improved pharmacological and process characteristics.
6 cl, 1 dwg, 3 tbl, 3 ex
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