FIELD: medicine; biotechnology.
SUBSTANCE: invention relates to biotechnology, virology, and medicine. Virions of adeno-associated virus (AAV) with optional capsid protein are presented, where AAV virions show high infection load of retinal cell at intravitreal injection compared with wild type AAV. Methods of delivering gene product in retinal cell of person and methods of treating eye diseases are also described.
EFFECT: virions of adeno-associated virus with optional capsid and methods for using them are presented.
24 cl, 25 dwg, 2 tbl, 3 ex
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