FIELD: biotechnology.
SUBSTANCE: dose of 200 mg/kg of streptozotocin is administered subcutaneously to male mice of C57Bl/6 line once, on the next day after birth. Then, on the 28th day after birth, the animals are transferred to a diet rich in saturated fats. This diet is maintained until hyperglycemia, hyperinsulinemia, glucose tolerance disorders, spermatogenesis depression and fertility disorders occur.
EFFECT: method provides simulation of hypogonadism caused by metabolic disorders, designed to find effective medicines correction of male reproductive system disorders in case of metabolic syndrome.
2 dwg, 6 tbl, 5 ex
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