METHOD FOR MODELLING MALE HYPOGONADOTROPIC HYPOGONADISM Russian patent published in 2021 - IPC A61B17/12 G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to endocrinology and experimental biology, and can be used to model male hypogonadotropic hypogonadism. Unilateral gonadectomy is performed in newborn male rats by means of removing the testicle from the intra-abdominal cavity, ligating, cutting the testicular cord, followed by removing the gonad. Unilateral gonadectomy is performed no later than on the 4^th day of postnatal life.

EFFECT: method provides a possibility of obtaining a model of male hypogonadism of hypogonadotropic form by performing unilateral gonadectomy in the early postnatal period of life, which, as opposed to a hypergonadotropic form of hypogonadism in analogs, allows modeling the hypogonadotropic form of hypogonadism in male rats.

1 cl, 4 dwg, 3 tbl