FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to production of analogues of oxyntomodulin and can be used in medicine for preventing or treating obesity. Modified peptide is obtained, which is capable to activate glucagon-like peptide-1 receptor (GLP-1) and glucagon receptor, containing amino acid sequence SEQ ID NO: 24, 25, 26 or 28.
EFFECT: invention increases activity of analogue in relation to glucagon-like peptide-1 receptor and glucagon receptor in comparison with native oxyntomodulin.
12 cl, 1 dwg, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONJUGATE, CONTAINING OXYNTOMODULIN AND FRAGMENT OF IMMUNOGLOBULIN, AND USE THEREOF | 2012 |
|
RU2607365C2 |
| NOVEL OXYNTOMODULIN DERIVATIVES AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM FOR TREATING OBESITY | 2012 |
|
RU2739209C2 |
| CONJUGATE CONTAINING OXINTOMODULIN AND IMMUNOGLOBULIN FRAGMENT, AND ITS APPLICATION | 2012 |
|
RU2733544C2 |
| COMPOSITION FOR HYPERLIPIDEMIA TREATMENT CONTAINING OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2642267C2 |
| COMPOSITION FOR TREATING HYPERLIPIDEMIA CONTAINING AN OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2768853C1 |
| OXYINTOMODULINE | 2009 |
|
RU2542362C2 |
| INSULIN-INCRETIN CONJUGATES | 2014 |
|
RU2678134C2 |
| CONJUGATE OF LONG-ACTING PHYSIOLOGICALLY ACTIVE SUBSTANCE AND ITS USE | 2018 |
|
RU2773823C2 |
| PHARMACEUTICAL COMPOSITION INCLUDING A POLYPEPTIDE | 2019 |
|
RU2777095C1 |
| AMIDE-BASED PRODRUGS OF GLUCAGON SUPERFAMILY PEPTIDES | 2009 |
|
RU2550696C2 |
