FIELD: chemistry.
SUBSTANCE: invention relates to a conjugate of the formula 1: X-L-F, where X is physiologically active substance, which is natural human insulin or human insulin analogue, which has reduced binding affinity relatively to an insulin receptor compared to natural insulin; L, being a linker, is polyethylene glycol with a size from more than 0 kDa to less than 3.4 kDa; and F is an immunoglobulin Fc area. A method for producing a conjugate and its composition is also proposed.
EFFECT: conjugate shows an increased half-life in vivo compared to a conjugate, which has the same X and F as this conjugate, but has another L as a linker, which is polyethylene glycol with a size of 3.4 kDa.
11 cl, 6 dwg, 6 ex
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