FIELD: medicine, pharmacy.
SUBSTANCE: pharmaceutical composition comprises 132.02 mg of potassium fimasartan trihydrate, 12.5 mg of hydrochlorothiazide and a binder, which binding solution has a viscosity from 20 mPa·s to 650 mPa·s. The binder includes at least one substance selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose and polyvinylpyrrolidone. A method for preparation of a pharmaceutical composition by wet granulation and a pill obtained in this manner are also described. This composition is characterized by a standard deviation (RSD) of 4.0% or less in the content uniformity test of the active ingredients. The uncoated pill has a crush strength of 7 Kp or more as per the invention.
EFFECT: invention refers to a pharmaceutical composition in the form of pill for hypertension treatment.
9 cl, 12 tbl, 11 ex
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